Feb 5, 2026

Natu-B4®: 22 years of innovation in natural choline with scientific validation

The evolution of animal nutrition in recent decades has been marked by a constant search for production efficiency, safety, and sustainability. In this scenario, choline has established itself as a strategic nutrient, mainly due to its role in energy and lipid metabolism. Over the years, what has changed is the approach adopted to meet this nutritional demand.

From the outset, Nuproxa approach to the development of Natu-B4® focused on understanding and scientifically proving how a polyherbal solution could act more broadly on animal metabolism, going beyond simply replacing synthetic choline chloride.

A scientifically based polyherbal innovation

Natu-B4® is formulated from carefully selected plants, used in their natural form, without chemical extractions. Among the species used are Solanum nigrum and Achyranthes aspera, which provide natural phospholipid conjugates, such as phosphatidylcholine, in addition to other bioactive compounds characteristic of the plant matrix.

Over more than 22 years of development, the product has been evaluated in more than 100 in vivo studies conducted at universities, research centers, and commercial facilities, involving more than 10 animal species.

This data set has resulted in the largest, most diverse, and most complete scientific dossier in the natural choline segment, reinforcing its position as the most validated solution on the market.

Why is scientific validation a distinguishing feature of natural choline?

One of Natu-B4®‘s most significant milestones is the scientific proof that supports its mode of action.

Studies described in Nuproxa technical materials show that the natural phospholipids present in Natu-B4® are associated with the activation of metabolic pathways related to PPAR-α (Peroxisome Proliferator-Activated Receptors), central regulators of fatty acid metabolism and energy utilization.

This metabolic approach differentiates Natu-B4® from conventional approaches, positioning it far beyond an herbal choline, but also as a natural modulator of energy metabolism, with consistent effects on nutrient utilization efficiency.

In which species has the effectiveness of Natu-B4® been proven?

Over more than two decades, studies conducted with Natu-B4® demonstrate its applicability in different production systems:

Poultry: studies indicate that Natu-B4® can be used as an alternative to choline chloride, with beneficial effects observed on production parameters.

Swine: available data point to an association with energy use efficiency and growth profile.

Ruminants: the product’s plant matrix is resistant to ruminal degradation, allowing metabolic effects after the rumen.

Pets: nutrigenomics studies described in technical materials indicate modulation of metabolic pathways associated with lipid and energy metabolism.

Technological stability, quality, and safety

In addition to its metabolic performance, Natu-B4® offers significant technological advantages. Because it is integrated into the plant matrix, its active compounds demonstrate high stability, do not interact negatively with vitamins or pigments, and maintain their integrity even under adverse temperature and humidity conditions.

Nuproxa adopts rigorous sanitation processes, such as gamma irradiation or organic acid treatments, ensuring low levels of microbiological contamination. The entire product line is FAMI-QS certified, in addition to ISO 9001, 14001, and 18001 certifications, ensuring traceability, quality, and environmental commitment.

Technical expertise as part of the solution

Polyherbal formulations require in-depth knowledge of raw materials, harvesting, processing, and the correct combination of plants. With over two decades of experience, Nuproxa has consolidated a technical and after-sales support model based on scientific documentation, consistent production, and close customer follow-up.

This set of factors reinforces that Natu-B4® is a nutritional solution built on applied knowledge and continuous validation.

Conclusion

After 22 years of research, validation, and practical application, Natu-B4® has established itself as a benchmark in natural choline for animal nutrition. Its unique selling point goes beyond its plant origin and is reinforced by scientific proof of its mode of action, the robustness of its technical dossier, and the efficiency of its results.

In a scenario where innovation needs to be supported by evidence, Natu-B4® represents a mature, validated solution that is aligned with the current demands of animal production.